This machine is suitable for laboratory and small batch production, and can realize the functions of top spray granulation and bottom spray coating. It integrates all the functional components required by the process, and features compact design, small floor area, free movement and high flexibility. It is very suitable for process research in scientific research institutes and pharmaceutical factories.

• It has the functions of drying, granulation and coating, and realizes different processes through
• The product containers for the following batches can be provided.
• Inflatable sealing gaskets are used between chambers to protect the operator, the machine and high-activity products.
• It is easy to change and wash bag filter because bag filter can be automatically raised and lowered.
• The outer surface of the machine is processed with wire drawing and the inner surface is polished, which are beautiful and easy to clean. The contact parts are made of SS316L and meet cGMP requirements.

This machine is suitable for laboratory and small batch production.

Wide-range batch production can be realized.

• Batch production of 1L, 3L, 6L, 10L and 15L can be realized by changing product containers.
• All parts in contact with the product are made of stainless steel AISI316L, with mirror finish on the inner surface, and the rest are made of sanitary stainless steel AISI304.
• cGMP compliance

P MINILAB coating machine uses the same high and new technology as the production coating machine, ensuring that it can produce various types of products, giving maximum flexibility and facilitating scale-up. It is highly automated and easy to operate and maintain.

It is suitable for laboratory and small batch production. Because of the interchangeability (applicable to three types of product containers), it can be applied to wide-range batch production.

Basic structure

After years of verification, the patented PELLIGRINI stirring blade ensures a perfect and uniform mixing.

Mixing performance and batch

The pan combined with the mixing baffles is positioned on the center of the drum. The mixing capability is maintained in case of minimum and maximum quantity of products, allowing a wide range of batches to be processed in the same machine (from 25% to 100% of the pan capacity).

Air flow direction

The position and size design of the exhaust devices ensure that the gas covers the same distance when it passes through the sheet bed, allowing better and homogeneous drying compared to other perforated pans while avoiding a 25% energy loss.

Exhaust duct

Exhaust devices are easy to disassemble and comply with the most stringent cGMP requirements.

Spray system

The sugar coating gun and film coating gun can be easily attached to the support arm. The film coating system is equipped with a peristaltic pump and a low-pressure plunger pump (depending on the product viscosity), as well as complete on-line pressure control and spray gun control.

S60 lab model was developed to support the generic consistency evaluation progress for pharmaceutical companies. This lab model can link up the process of R&D, pilot production and industrial production. S60 is modular design and can change turret quickly which enable user to upgrade it to pilot production model at low cost.

Scope of application:

• Small dose tablet (single press at least)
• Process research
• Analysis and comparison of experimental data
• Powder is directly pressed into tablets
• Pill tablet press
• Micro-tablet press (≤2mm)
• Effervescent tablet press
• Bi-layer tablet compression

This machine is a MINI capsule machine specially designed for laboratories.

It is currently the only series lab machine using tube filling in China.

Accurate filling

The filling accuracy within 2% can be achieved by using unique tube filling device and adjusting process parameters.

Optimized function and easy operation

The change of parts for different specifications and the cleaning of filling area are fast, simple and easy. Only one special tool is needed for changing parts, and the changing time is controlled within 15 minutes.

Stability and flexibility

Small floor area, light weight, flexible and convenient transportation.

Combined filling

The filling methods are flexible and varied, and different medicines can be filled in the same capsule, and the combination of up to four materials can be filled.

The horizontal screw feeding method is characterized by wide adaptability of materials, high molding rate, good impermeability and easy cleaning and maintenance.

Material supply stirring part

The hopper is equipped with a screw mixing device, in which the materials can be transported uniformly, preventing the suspension of the bridge. The hopper is equipped with an exhaust device that can discharge excess air in the material in time.

Horizontal screw feed part

DG150 adopts double-stage screw to feed, ensuring the material distribution in roller

In the process of horizontal screw feeding, a vacuum exhaust system is provided to remove the air generated during the material compression process and guarantee the yield of the material.

ROLL FORMING PART

A closed loop system is formed to control the feeding screw speed and the roller gap to ensure a constant roller gap. The control precise of roller clearance is ±0.1mm

The hydraulic system adopts the patented automatic compensation control system, which always ensures that the two rollers are parallel in the working process. To ensure the thickness of the finished product is even. Pressure control accuracy of roller is + / – 1bar.

The roller part is equipped with water cooling system to control temperature rise and prevent material deactivation or property change at high temperature.

For different materials, we can provide a variety of surface shape roller, such as straight lines, smooth, knurling, etc.

Crushing part

the rotary speed of crushing knife can be adjusted without step. The lower end of the crushing part is equipped with a sampling port, which can detect the material in time.

The DG150 is equipped with a two-stage granulation system, and the two-stage granulation knife can be driven independently. Different rotating speeds can be set to ensure materials homogeneity after the granulation.

There are a variety of specifications and models of weaving and punching network for selection.

The clearance between the sieve and knife can be manually adjusted by an external knob.

The lower end of the granulation system is provided with a sampling port, which can detect the material in time.

The discharge port is divided into main channel and fine powder channel. Finished particles are discharged from the main channel. The fine powder channel is connected with the vacuum feeder, which can implement the roller pressing circulation.

Positive pressure containment system of transmission shaft

The advanced positive pressure containment system is used at the contact part of material and rotating shaft to prevent cross contamination in transmission area and production area.

Positive pressure containment system with damage detection function can further ensure the sealing effect.

Easy to disassemble and assemble, easy to clean

The equipment adopts quick installation design. The parts can be disassembled and installed easily with normal tools.

The parts can be disassembled thoroughly and easy to be cleaned.

Extreme versatility to achieve great results for each kind of process

Easily integrated with other granulation equipment for highly automated and contained installations

With the increase of the requirement for the production and development equipment of highly isolated powder treatment, granulation, tablet press, capsule filling and coating, SMA launched the laboratory and production highly isolated containment solid preparation line in time to meet the market demand.

The design of containment equipment must be a risk-based solution which needs a preliminary analysis of key and potential risks for pharmaceutical processes and factory conditions, regulations, layouts, and industrial objectives.

The inlet and outlet of the highly active powder is conducted through the sealing αβ valves. The containment cavity adopts the inflatable sealing, and does not deflate after power off, ensuring complete sealing and production area isolation.

The containment cavity is made of stainless steel AISI304, and the micro negative pressure is maintained during production.

The side door is automatically locked and tested when the machine is turned on, and inflatable sealing is used to prevent operators from being hurt by wrong operation.

Clean air passing through primary, medium and high efficiency filters will be sent to the host machine by the pressure fan; the exhaust air disposed by the high efficiency filter through the dust collector and the bag-in-bag-out system and will be discharged to outside. During the whole production process, the host machine cavity is kept with a micro- negative pressure of about -50pa.

All parts in contact with the product will be moistened or cleaned online with more strictly and complex principle before removal according to operational risk control analysis.

S60 is modular design and can change turret quickly which enable User to upgrade trial run model at low cost.

S60 FUNCTION & DESINE FEATURES

Interchangeable turret (multiple turret optional)Hand wheel adjustment(optional servo motor control)

Quick speed adjustment by potentiometer (touch screen control as option) multiple loading options

Gravity Loading

Small volume compression, fill cam with position device to prevent fault installation